Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION

In yeast, fragmentation of amyloid polymers by the Hsp104 chaperone allows them to propagate as prions. The prion-forming domain of the yeast Sup35 protein is rich in glutamine, asparagine, tyrosine, and glycine residues, which may define its prion properties. Long polyglutamine stretches can also d...

Descripción completa

Detalles Bibliográficos
Autores principales: Alexandrov, Ilya M., Vishnevskaya, Aleksandra B., Ter-Avanesyan, Michael D., Kushnirov, Vitaly V.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397454/
https://www.ncbi.nlm.nih.gov/pubmed/18381282
http://dx.doi.org/10.1074/jbc.M802071200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397454/
https://www.ncbi.nlm.nih.gov/pubmed/18381282
http://dx.doi.org/10.1074/jbc.M802071200

Ejemplares similares