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Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION

In yeast, fragmentation of amyloid polymers by the Hsp104 chaperone allows them to propagate as prions. The prion-forming domain of the yeast Sup35 protein is rich in glutamine, asparagine, tyrosine, and glycine residues, which may define its prion properties. Long polyglutamine stretches can also d...

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Detalles Bibliográficos
Autores principales:	Alexandrov, Ilya M., Vishnevskaya, Aleksandra B., Ter-Avanesyan, Michael D., Kushnirov, Vitaly V.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397454/ https://www.ncbi.nlm.nih.gov/pubmed/18381282 http://dx.doi.org/10.1074/jbc.M802071200

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