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Lack of Interferon (IFN) Response to T7 Transcribed pppG (n)(n = 2,3)-shRNA

RNA interference (RNAi) mediated by siRNAs has proved to be a highly effective gene silencing mechanism with great potential for gene therapeutic applications. However, siRNA agents have been shown to exert non-target-related biological effects and toxicities, including immune stimulation. Specifica...

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Detalles Bibliográficos
Autores principales: Gondai, Takuma, Yamaguchi, Kazuya, Hashimoto, Kahoko, Miyano-Kurosaki, Naoko, Takaku, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Taylor & Francis Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2403744/
https://www.ncbi.nlm.nih.gov/pubmed/18066904
http://dx.doi.org/10.1080/15257770701503647