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Modular Organization and Combinatorial Energetics of Proline–Tyrosine Nuclear Localization Signals

Proline–tyrosine nuclear localization signals (PY-NLSs) are recognized and transported into the nucleus by human Karyopherin (Kap) β2/Transportin and yeast Kap104p. Multipartite PY-NLSs are highly diverse in sequence and structure, share a common C-terminal R/H/KX(2–5)PY motif, and can be subdivided...

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Detalles Bibliográficos
Autores principales: Süel, Katherine E, Gu, Hongmei, Chook, Yuh Min
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408616/
https://www.ncbi.nlm.nih.gov/pubmed/18532879
http://dx.doi.org/10.1371/journal.pbio.0060137