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Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas

BACKGROUND: We have used a mouse model based on overexpression of c-Myc in B cells genetically engineered to be self-reactive to test the hypothesis that farnesyl transferase inhibitors (FTIs) can effectively treat mature B cell lymphomas. FTIs are undergoing clinical trials to treat both lymphoid a...

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Detalles Bibliográficos
Autores principales:	Field, Kenneth A, Charoenthongtrakul, Soratree, Bishop, J Michael, Refaeli, Yosef
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409375/ https://www.ncbi.nlm.nih.gov/pubmed/18489761 http://dx.doi.org/10.1186/1476-4598-7-39

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