A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers

Variation in the penetrance estimates for BRCA1 and BRCA2 mutation carriers suggests that other genetic polymorphisms may modify the cancer risk in carriers. The RAD51 gene, which participates in homologous recombination double-strand breaks (DSB) repair in the same pathway as the BRCA1 and BRCA2 ge...

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Detalles Bibliográficos
Autores principales: Kadouri, L, Kote-Jarai, Z, Hubert, A, Durocher, F, Abeliovich, D, Glaser, B, Hamburger, T, Eeles, R A, Peretz, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409456/
https://www.ncbi.nlm.nih.gov/pubmed/15138485
http://dx.doi.org/10.1038/sj.bjc.6601837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409456/
https://www.ncbi.nlm.nih.gov/pubmed/15138485
http://dx.doi.org/10.1038/sj.bjc.6601837

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