The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)

In this report we show that mithramycin considerably increases the direct cytotoxic effect of tumour necrosis factor (TNF) on tumour cells in vitro. Sensitisation to TNF-induced apoptosis was prevented by the broad caspase inhibitor zVAD-fmk, whereas overexpression of Bcl-2 had no effect. Mithramyci...

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Detalles Bibliográficos
Autores principales: Duverger, V, Murphy, A-M, Sheehan, D, England, K, Cotter, T G, Hayes, I, Murphy, F J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409467/
https://www.ncbi.nlm.nih.gov/pubmed/15138489
http://dx.doi.org/10.1038/sj.bjc.6601824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409467/
https://www.ncbi.nlm.nih.gov/pubmed/15138489
http://dx.doi.org/10.1038/sj.bjc.6601824

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