Activity (transcription) of the genes for MLH1, MSH2 and p53 in sporadic colorectal tumours with micro-satellite instability

Micro-satellite instability (MSI) is relevant in the management of colorectal cancers (CRC) and relies on analysis of gene mutations, or production of the proteins involved in DNA mismatch repair (e.g. MLH1, MSH2). p53 mutation is also relevant in MSI, but high-level CRC (MSI-H) demonstrate fewer mu...

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Detalles Bibliográficos
Autores principales: Tou, S I H, Drye, E R, Boulos, P B, Hollingsworth, S J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409469/
https://www.ncbi.nlm.nih.gov/pubmed/15138486
http://dx.doi.org/10.1038/sj.bjc.6601823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409469/
https://www.ncbi.nlm.nih.gov/pubmed/15138486
http://dx.doi.org/10.1038/sj.bjc.6601823

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