Improved biological activity of a mutant endostatin containing a single amino-acid substitution

Human endostatin has an internal Asn-Gly-Arg (NGR) motif at position 126–128 following a proline at position 125. Asn-Gly-Arg-containing peptides have been shown to target tumour vasculature and inhibit aminopeptidase N activity. We previously compared the in vitro and in vivo biological activities...

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Detalles Bibliográficos
Autores principales: Yokoyama, Y, Ramakrishnan, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409698/
https://www.ncbi.nlm.nih.gov/pubmed/15083196
http://dx.doi.org/10.1038/sj.bjc.6601745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409698/
https://www.ncbi.nlm.nih.gov/pubmed/15083196
http://dx.doi.org/10.1038/sj.bjc.6601745

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