A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents

An early step in the carcinogenesis of hereditary non-polyposis colorectal cancer (HNPCC) and some sporadic colorectal cancers (CRCs) is the acquisition of a ‘mutator phenotype’ resulting from defects in DNA mismatch repair (MMR) genes, which normally maintain genomic stability. This mutator phenoty...

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Detalles Bibliográficos
Autores principales: Parker, A R, Leonard, C P, Hua, L, Francis, R O, Dhara, S, Maitra, A, Eshleman, J R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409721/
https://www.ncbi.nlm.nih.gov/pubmed/15083201
http://dx.doi.org/10.1038/sj.bjc.6601740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409721/
https://www.ncbi.nlm.nih.gov/pubmed/15083201
http://dx.doi.org/10.1038/sj.bjc.6601740

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