Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis

Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular tracking, we were able to show that MLL cleavage preceded gene rearrangement by 3 months...

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Autores principales: Ng, A, Ravetto, P F, Taylor, G M, Wynn, R F, Eden, O B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409780/
https://www.ncbi.nlm.nih.gov/pubmed/15570305
http://dx.doi.org/10.1038/sj.bjc.6602269
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author Ng, A
Ravetto, P F
Taylor, G M
Wynn, R F
Eden, O B
author_facet Ng, A
Ravetto, P F
Taylor, G M
Wynn, R F
Eden, O B
author_sort Ng, A
collection PubMed
description Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular tracking, we were able to show that MLL cleavage preceded gene rearrangement by 3 months and before the clinical diagnosis of t-AML in a patient with haemophagocytic lymphohistiocytosis. This is the first report on the sequential detection of the two biomarkers in treatment-related leukaemogenesis.
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spelling pubmed-24097802009-09-10 Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis Ng, A Ravetto, P F Taylor, G M Wynn, R F Eden, O B Br J Cancer Short Communication Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular tracking, we were able to show that MLL cleavage preceded gene rearrangement by 3 months and before the clinical diagnosis of t-AML in a patient with haemophagocytic lymphohistiocytosis. This is the first report on the sequential detection of the two biomarkers in treatment-related leukaemogenesis. Nature Publishing Group 2004-12-13 2004-11-30 /pmc/articles/PMC2409780/ /pubmed/15570305 http://dx.doi.org/10.1038/sj.bjc.6602269 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Ng, A
Ravetto, P F
Taylor, G M
Wynn, R F
Eden, O B
Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
title Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
title_full Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
title_fullStr Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
title_full_unstemmed Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
title_short Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
title_sort coexistence of treatment-related mll cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409780/
https://www.ncbi.nlm.nih.gov/pubmed/15570305
http://dx.doi.org/10.1038/sj.bjc.6602269
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