Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment

Inhibitors of glycogen breakdown regulate glucose homeostasis by limiting glucose production in diabetes. Here we demonstrate that restrained glycogen breakdown also inhibits cancer cell proliferation and induces apoptosis through limiting glucose oxidation, as well as nucleic acid and de novo fatty...

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Detalles Bibliográficos
Autores principales: Lee, W-N P, Guo, P, Lim, S, Bassilian, S, Lee, S T, Boren, J, Cascante, M, Go, V L W, Boros, L G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409791/
https://www.ncbi.nlm.nih.gov/pubmed/15599384
http://dx.doi.org/10.1038/sj.bjc.6602243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409791/
https://www.ncbi.nlm.nih.gov/pubmed/15599384
http://dx.doi.org/10.1038/sj.bjc.6602243

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