Reduced expression of small GTPases and hypermethylation of the folate binding protein gene in cisplatin-resistant cells

Reduced accumulation of cisplatin is the most consistent feature seen in cisplatin-resistant (CP-r) cells that are cross-resistant to other cytotoxic compounds, such as methotrexate. In this report, defective uptake of a broad range of compounds, including [(14)C]-carboplatin, [(3)H]MTX, [(3)H]folic...

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Detalles Bibliográficos
Autores principales: Shen, D-W, Su, A, Liang, X-J, Pai-Panandiker, A, Gottesman, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409801/
https://www.ncbi.nlm.nih.gov/pubmed/15199393
http://dx.doi.org/10.1038/sj.bjc.6601956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409801/
https://www.ncbi.nlm.nih.gov/pubmed/15199393
http://dx.doi.org/10.1038/sj.bjc.6601956

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