Targeted radiosensitisation by pegylated liposome-encapsulated 3′, 5′-O-dipalmitoyl 5-iodo-2′-deoxyuridine in a head and neck cancer xenograft model

5-Iodo-2′-deoxyuridine (IUdR) is an effective radiosensitiser but its clinical development has been limited by toxicity. Prolonged intravenous infusions of IUdR are necessary for optimal tumour uptake but cause dose-limiting myelosuppression. The lack of selective tumour uptake can lead to radiosens...

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Detalles Bibliográficos
Autores principales: Harrington, K J, Syrigos, K N, Uster, P S, Zetter, A, Lewanski, C R, Gullick, W J, Vile, R G, Stewart, J S W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409821/
https://www.ncbi.nlm.nih.gov/pubmed/15199395
http://dx.doi.org/10.1038/sj.bjc.6601958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409821/
https://www.ncbi.nlm.nih.gov/pubmed/15199395
http://dx.doi.org/10.1038/sj.bjc.6601958

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