Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation

In prostate carcinoma (PCa) increased DNA methylation (‘hypermethylation’) occurs at specific genes such as GSTP1. Nevertheless, overall methylation can be decreased (‘hypomethylation’) because methylation of repetitive sequences like LINE-1 retrotransposons is diminished. We analysed DNA from 113 P...

Descripción completa

Detalles Bibliográficos
Autores principales: Florl, A R, Steinhoff, C, Müller, M, Seifert, H-H, Hader, C, Engers, R, Ackermann, R, Schulz, W A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409889/
https://www.ncbi.nlm.nih.gov/pubmed/15292941
http://dx.doi.org/10.1038/sj.bjc.6602030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409889/
https://www.ncbi.nlm.nih.gov/pubmed/15292941
http://dx.doi.org/10.1038/sj.bjc.6602030

Ejemplares similares