Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody formation was observed, offering possibilities fo...

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Autores principales: van Etten, B, Eggermont, A M M, Ambagtsheer, G, van Tiel, S T, ten Hagen, T L M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409916/
https://www.ncbi.nlm.nih.gov/pubmed/15480435
http://dx.doi.org/10.1038/sj.bjc.6602151
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author van Etten, B
Eggermont, A M M
Ambagtsheer, G
van Tiel, S T
ten Hagen, T L M
author_facet van Etten, B
Eggermont, A M M
Ambagtsheer, G
van Tiel, S T
ten Hagen, T L M
author_sort van Etten, B
collection PubMed
description Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.
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spelling pubmed-24099162009-09-10 Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors van Etten, B Eggermont, A M M Ambagtsheer, G van Tiel, S T ten Hagen, T L M Br J Cancer Short Communication Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings. Nature Publishing Group 2004-10-18 2004-10-12 /pmc/articles/PMC2409916/ /pubmed/15480435 http://dx.doi.org/10.1038/sj.bjc.6602151 Text en Copyright © 2004 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
van Etten, B
Eggermont, A M M
Ambagtsheer, G
van Tiel, S T
ten Hagen, T L M
Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
title Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
title_full Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
title_fullStr Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
title_full_unstemmed Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
title_short Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
title_sort impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409916/
https://www.ncbi.nlm.nih.gov/pubmed/15480435
http://dx.doi.org/10.1038/sj.bjc.6602151
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AT vantielst impairedneutralisingantibodyformationandhightransductionefficacyafterisolatedhepaticperfusionwithadenoviralvectors
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