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Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
mTOR is a downstream mediator in the PI3K/Akt signalling pathway, which plays a critical role in regulating basic cellular functions. These include cell proliferation, survival, mobility and angiogenesis. Rapamycin and its analogues (CCI-779, RAD001 and AP23573) have specific antagonistic action on...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409926/ https://www.ncbi.nlm.nih.gov/pubmed/15365568 http://dx.doi.org/10.1038/sj.bjc.6602162 |