A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer

The purpose of this phase II trial was to compare the efficacy, safety and pharmacokinetics of four irinotecan schedules for the treatment of metastatic colorectal cancer. In total, 174 5-fluorouracil pretreated patients were randomised to: arm A (n=41), 350 mg m(−2) irinotecan as a 90-min i.v. infu...

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Detalles Bibliográficos
Autores principales: Schoemaker, N E, Kuppens, I E L M, Moiseyenko, V, Glimelius, B, Kjaer, M, Starkhammer, H, Richel, D J, Smaaland, R, Bertelsen, K, Poulsen, J P, Voznyi, E, Norum, J, Fennelly, D, Tveit, K M, Garin, A, Gruia, G, Mourier, A, Sibaud, D, Lefebvre, P, Beijnen, J H, Schellens, J H M, ten Bokkel Huinink, W W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409929/
https://www.ncbi.nlm.nih.gov/pubmed/15381932
http://dx.doi.org/10.1038/sj.bjc.6602172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409929/
https://www.ncbi.nlm.nih.gov/pubmed/15381932
http://dx.doi.org/10.1038/sj.bjc.6602172

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