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Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer
Proliferating cells, especially tumour cells, express a special isoenzyme of pyruvate kinase, termed M2-PK, which can occur in a tetrameric form with a high affinity to its substrate, phosphoenolpyruvate (PEP), and in a dimeric form with a low PEP affinity. In tumour cells, the dimeric form is usual...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409989/ https://www.ncbi.nlm.nih.gov/pubmed/15266315 http://dx.doi.org/10.1038/sj.bjc.6602033 |