Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells

The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumour suppressor is mutated in 40–50% of human endometrial cancers. PTEN exerts its effects in part via inhibition of the antiapoptotic protein AKT. We demonstrate that two endometrial cancer cell lines that harbour PTEN mutations,...

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Detalles Bibliográficos
Autores principales: Jin, X, Gossett, D R, Wang, S, Yang, D, Cao, Y, Chen, J, Guo, R, Reynolds, R K, Lin, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410058/
https://www.ncbi.nlm.nih.gov/pubmed/15505622
http://dx.doi.org/10.1038/sj.bjc.6602214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410058/
https://www.ncbi.nlm.nih.gov/pubmed/15505622
http://dx.doi.org/10.1038/sj.bjc.6602214

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