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Additive interaction of gefitinib (‘Iressa’, ZD1839) and ionising radiation in human tumour cells in vitro

Cultures of human carcinoma A-431, A-549 and HeLa cells were challenged with γ-rays without or with concomitant exposure to gefitinib, a potent inhibitor of the tyrosine kinase activity of epidermal growth factor receptor (EGFR). The outcome of treatment was determined from cell and colony count, ce...

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Detalles Bibliográficos
Autores principales: Giocanti, N, Hennequin, C, Rouillard, D, Defrance, R, Favaudon, V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410146/
https://www.ncbi.nlm.nih.gov/pubmed/15545965
http://dx.doi.org/10.1038/sj.bjc.6602242