CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes

Ifosfamide is a prodrug that requires bioactivation by cytochrome P450 for antitumour activity. Up to now, little is known, to what extent in addition to the liver the ifosfamide metabolism may occur intratumorally. For this purpose, we investigated the expression of CYP3A4, CYP2C9 and CYP2B6 in bre...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, R, Baumann, F, Knüpfer, H, Brauckhoff, M, Horn, L-C, Schönfelder, M, Köhler, U, Preiss, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410158/
https://www.ncbi.nlm.nih.gov/pubmed/14970873
http://dx.doi.org/10.1038/sj.bjc.6601492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410158/
https://www.ncbi.nlm.nih.gov/pubmed/14970873
http://dx.doi.org/10.1038/sj.bjc.6601492

Ejemplares similares