The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis

In response to DNA damage, the cell cycle checkpoint kinase 2 (CHEK2) may phosphorylate p53, Cdc25A and Cdc25C, and regulate BRCA1 function, leading to cell cycle arrest and DNA repair. The truncating germline mutation CHEK2(*)1100delC abrogates kinase activity and confers low-penetrance susceptibil...

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Detalles Bibliográficos
Autores principales: Koppert, L B, Schutte, M, Abbou, M, Tilanus, H W, Dinjens, W N M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410163/
https://www.ncbi.nlm.nih.gov/pubmed/14970869
http://dx.doi.org/10.1038/sj.bjc.6601551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410163/
https://www.ncbi.nlm.nih.gov/pubmed/14970869
http://dx.doi.org/10.1038/sj.bjc.6601551

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