N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx

Anticancer drugs generally have intracellular targets, implicating transport over the plasma membrane. For amphiphilic agents, such as the anthracycline doxorubicin, this occurs by passive diffusion. We investigated whether exogenous membrane-permeable lipid analogues improve this drug influx. Combi...

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Detalles Bibliográficos
Autores principales: Veldman, R J, Zerp, S, van Blitterswijk, W J, Verheij, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410169/
https://www.ncbi.nlm.nih.gov/pubmed/14970874
http://dx.doi.org/10.1038/sj.bjc.6601581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410169/
https://www.ncbi.nlm.nih.gov/pubmed/14970874
http://dx.doi.org/10.1038/sj.bjc.6601581

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