Cargando…

Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats

In preclinical studies, BNP7787 (disodium 2,2′-dithio-bis-ethane sulphonate), the disulphide form of mesna, has demonstrated selective protection against cisplatin-induced nephrotoxicity due to conversion into mesna inactivating toxic platinum species. Mesna (sodium 2-mercapto ethane sulphonate), ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Verschraagen, M, Boven, E, Torun, E, Erkelens, C A M, Hausheer, F H, van der Vijgh, W J F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410273/
https://www.ncbi.nlm.nih.gov/pubmed/15083199
http://dx.doi.org/10.1038/sj.bjc.6601719