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Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats
In preclinical studies, BNP7787 (disodium 2,2′-dithio-bis-ethane sulphonate), the disulphide form of mesna, has demonstrated selective protection against cisplatin-induced nephrotoxicity due to conversion into mesna inactivating toxic platinum species. Mesna (sodium 2-mercapto ethane sulphonate), ho...
Autores principales: | Verschraagen, M, Boven, E, Torun, E, Erkelens, C A M, Hausheer, F H, van der Vijgh, W J F |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410273/ https://www.ncbi.nlm.nih.gov/pubmed/15083199 http://dx.doi.org/10.1038/sj.bjc.6601719 |
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