SFRP-4 abrogates Wnt-3a-induced β-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation

BACKGROUND: Conserved Wnt ligands are critical for signalling during development; however, various factors modulate their activity. Among these factors are the Secreted Frizzled-Related Proteins (SFRP). We previously isolated the SFRP-4 gene from an involuting rat mammary gland and later showed that...

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Detalles Bibliográficos
Autores principales: Constantinou, Thecla, Baumann, Fabrizio, Lacher, Markus D, Saurer, Susanne, Friis, Robert, Dharmarajan, Arun
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2412851/
https://www.ncbi.nlm.nih.gov/pubmed/18452624
http://dx.doi.org/10.1186/1750-2187-3-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2412851/
https://www.ncbi.nlm.nih.gov/pubmed/18452624
http://dx.doi.org/10.1186/1750-2187-3-10

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