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Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice
Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigen-driven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antige...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413022/ https://www.ncbi.nlm.nih.gov/pubmed/18519651 http://dx.doi.org/10.1084/jem.20081057 |