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Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

To define the roles of endothelial-intrinsic nuclear factor κB (NF-κB) activity in host defense and multiple organ injury in response to sepsis, we generated double transgenic (TG) mice (EC-rtTA/I-κBαmt) that conditionally overexpress a degradation-resistant form of the NF-κB inhibitor I-κBα (I-κBαm...

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Detalles Bibliográficos
Autores principales: Ye, Xiaobing, Ding, Jianqiang, Zhou, Xiaozhou, Chen, Guoqian, Liu, Shu Fang
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413029/
https://www.ncbi.nlm.nih.gov/pubmed/18474628
http://dx.doi.org/10.1084/jem.20071393