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Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM(+)IgD(+)CD27(+) B cell repertoire in infants
T cell–dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell–independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as “IgM memory” B cells), comparing these cells with sw...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413031/ https://www.ncbi.nlm.nih.gov/pubmed/18519648 http://dx.doi.org/10.1084/jem.20071555 |