Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

DNA double strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homology-directed repair (HR). HR requires nucleolytic degradation of 5′ DNA ends to generate tracts of single-stranded DNA (ssDNA), which are also important for the activation of DNA damage checkpoints. Here we...

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Detalles Bibliográficos
Autores principales: Zierhut, Christian, Diffley, John F X
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413190/
https://www.ncbi.nlm.nih.gov/pubmed/18511906
http://dx.doi.org/10.1038/emboj.2008.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413190/
https://www.ncbi.nlm.nih.gov/pubmed/18511906
http://dx.doi.org/10.1038/emboj.2008.111

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