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Cytosolic Sequestration of Prep1 Influences Early Stages of T Cell Development

OBJECTIVE: Prep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic mice. To further investigate the role of this h...

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Detalles Bibliográficos
Autores principales: Penkov, Dmitry, Palazzolo, Martina, Mondino, Anna, Blasi, Francesco
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413408/
https://www.ncbi.nlm.nih.gov/pubmed/18560600
http://dx.doi.org/10.1371/journal.pone.0002424