Incompatibilities Involving Yeast Mismatch Repair Genes: A Role for Genetic Modifiers and Implications for Disease Penetrance and Variation in Genomic Mutation Rates

Genetic background effects underlie the penetrance of most genetically determined phenotypes, including human diseases. To explore how such effects can modify a mutant phenotype in a genetically tractable system, we examined an incompatibility involving the MLH1 and PMS1 mismatch repair genes using...

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Detalles Bibliográficos
Autores principales: Demogines, Ann, Wong, Alex, Aquadro, Charles, Alani, Eric
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413424/
https://www.ncbi.nlm.nih.gov/pubmed/18566663
http://dx.doi.org/10.1371/journal.pgen.1000103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413424/
https://www.ncbi.nlm.nih.gov/pubmed/18566663
http://dx.doi.org/10.1371/journal.pgen.1000103

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