Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1-Elicited Syncytia

DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes an activating phosphorylation in syncytia elicited by the envelope glycoprotein complex (Env) of human...

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Detalles Bibliográficos
Autores principales: Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, Manic, Gwenola, Rosselli, Filippo, Amendola, Alessandra, Masdehors, Peggy, Chessa, Luciana, Novelli, Giuseppe, Ojcius, David M., Siwicki, Jan Konrad, Chechlinska, Magdalena, Auclair, Christian, Regueiro, José R., de Thé, Hugues, Gougeon, Marie-Lise, Piacentini, Mauro, Kroemer, Guido
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423469/
https://www.ncbi.nlm.nih.gov/pubmed/18560558
http://dx.doi.org/10.1371/journal.pone.0002458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423469/
https://www.ncbi.nlm.nih.gov/pubmed/18560558
http://dx.doi.org/10.1371/journal.pone.0002458

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