Germline Mutation in RNASEL Predicts Increased Risk of Head and Neck, Uterine Cervix and Breast Cancer

THE BACKGROUND: Ribonuclease L (RNASEL), encoding the 2′-5′-oligoadenylate (2-5A)-dependent RNase L, is a key enzyme in the interferon induced antiviral and anti-proliferate pathway. Mutations in RNASEL segregate with the disease in prostate cancer families and specific genotypes are associated with...

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Detalles Bibliográficos
Autores principales: Madsen, Bo Eskerod, Ramos, Eliana Marisa, Boulard, Mathieu, Duda, Katarzyna, Overgaard, Jens, Nordsmark, Marianne, Wiuf, Carsten, Hansen, Lise Lotte
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424240/
https://www.ncbi.nlm.nih.gov/pubmed/18575592
http://dx.doi.org/10.1371/journal.pone.0002492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424240/
https://www.ncbi.nlm.nih.gov/pubmed/18575592
http://dx.doi.org/10.1371/journal.pone.0002492

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