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Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo
The zebrafish u-boot (ubo) gene encodes the transcription factor Prdm1, which is essential for the specification of the primary slow-twitch muscle fibres that derive from adaxial cells. Here, we show that Prdm1 functions by acting as a transcriptional repressor and that slow-twitch-specific muscle g...
Autores principales: | von Hofsten, Jonas, Elworthy, Stone, Gilchrist, Michael J, Smith, James C, Wardle, Fiona C, Ingham, Philip W |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424280/ https://www.ncbi.nlm.nih.gov/pubmed/18535625 http://dx.doi.org/10.1038/embor.2008.73 |
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