Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation

Sequence-specific targeting of genomic DNA by triplex-forming oligonucleotides (TFOs) is a promising strategy to modulate in vivo gene expression. Triplex formation involving G-rich oligonucleotides as third strand is, however, strongly inhibited by potassium-induced TFO self-association into G-quar...

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Detalles Bibliográficos
Autores principales: Paramasivam, Manikandan, Cogoi, Susanna, Filichev, Vyacheslav V., Bomholt, Niels, Pedersen, Erik B., Xodo, Luigi E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425464/
https://www.ncbi.nlm.nih.gov/pubmed/18456705
http://dx.doi.org/10.1093/nar/gkn242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425464/
https://www.ncbi.nlm.nih.gov/pubmed/18456705
http://dx.doi.org/10.1093/nar/gkn242

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