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Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. Hairpins are therefore considered likely intermediates during the expansion pr...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425488/ https://www.ncbi.nlm.nih.gov/pubmed/18440969 http://dx.doi.org/10.1093/nar/gkn225 |