Crystal structure of trioxacarcin A covalently bound to DNA

We report a crystal structure that shows an antibiotic that extracts a nucleobase from a DNA molecule ‘caught in the act’ after forming a covalent bond but before departing with the base. The structure of trioxacarcin A covalently bound to double-stranded d(AACCGGTT) was determined to 1.78 Å resolut...

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Detalles Bibliográficos
Autores principales: Pfoh, Roland, Laatsch, Hartmut, Sheldrick, George M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425490/
https://www.ncbi.nlm.nih.gov/pubmed/18453630
http://dx.doi.org/10.1093/nar/gkn245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425490/
https://www.ncbi.nlm.nih.gov/pubmed/18453630
http://dx.doi.org/10.1093/nar/gkn245

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