Cargando…

Crystal structure of trioxacarcin A covalently bound to DNA

We report a crystal structure that shows an antibiotic that extracts a nucleobase from a DNA molecule ‘caught in the act’ after forming a covalent bond but before departing with the base. The structure of trioxacarcin A covalently bound to double-stranded d(AACCGGTT) was determined to 1.78 Å resolut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pfoh, Roland, Laatsch, Hartmut, Sheldrick, George M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425490/ https://www.ncbi.nlm.nih.gov/pubmed/18453630 http://dx.doi.org/10.1093/nar/gkn245

Ejemplares similares

Formation of gutingimycin: analytical investigation of trioxacarcin A-mediated alkylation of dsDNA
por: Fitzner, Ansgar, et al.
Publicado: (2008)

Solution structures of DNA-bound gyrase
por: Baker, Nicole M., et al.
Publicado: (2011)

Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis
por: Maté, María J., et al.
Publicado: (2012)

Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation
por: König, Bettina, et al.
Publicado: (2009)

Assembly and structural analysis of a covalently closed nano-scale DNA cage
por: Andersen, Felicie F., et al.
Publicado: (2008)

The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding
por: Le, Tung B. K., et al.
Publicado: (2011)

The structure of SgrAI bound to DNA; recognition of an 8 base pair target
por: Dunten, Pete W., et al.
Publicado: (2008)

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
por: Littler, D. R., et al.
Publicado: (2010)

Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1
por: Hou, Caixia, et al.
Publicado: (2016)

Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly
por: He, Ju, et al.
Publicado: (2011)

Conformational tuning of a DNA-bound transcription factor
por: Sicoli, Giuseppe, et al.
Publicado: (2019)

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome
por: Schmidt, Christian, et al.
Publicado: (2016)

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate
por: Lu, Cheng, et al.
Publicado: (2011)

Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA
por: Moréra, Solange, et al.
Publicado: (2012)

The crystal structure of the Thermus aquaticus DnaB helicase monomer
por: Bailey, Scott, et al.
Publicado: (2007)

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
por: Lin, Sheng, et al.
Publicado: (2021)

Crystal structures and identification of novel Cd(2+)-specific DNA aptamer
por: Liu, Hehua, et al.
Publicado: (2023)

Structure and activity of the only human RNase T2
por: Thorn, Andrea, et al.
Publicado: (2012)

Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction
por: Day, Matthew, et al.
Publicado: (2022)

The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA
por: Lo, Yu-Hua, et al.
Publicado: (2009)

Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer
por: Lin, Jason L. J., et al.
Publicado: (2016)

Double threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine–thymine mismatch
por: Jourdan, Muriel, et al.
Publicado: (2012)

Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence
por: Scarsdale, J. Neel, et al.
Publicado: (2011)

High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label
por: Heinz, Marcel, et al.
Publicado: (2020)

Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA
por: Meinke, Gretchen, et al.
Publicado: (2017)

DNA phosphate crowding correlates with protein cationic side chain density and helical curvature in protein/DNA crystal structures
por: Grant, Bryce N., et al.
Publicado: (2013)

Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
por: Belorusova, Anna Y, et al.
Publicado: (2020)

ST1710–DNA complex crystal structure reveals the DNA binding mechanism of the MarR family of regulators
por: Kumarevel, Thirumananseri, et al.
Publicado: (2009)

Structure of mycobacterial 3′-to-5′ RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases
por: Ejaz, Anam, et al.
Publicado: (2018)

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages
por: Clark, George R., et al.
Publicado: (2012)

Extreme divergence between one-to-one orthologs: the structure of N15 Cro bound to operator DNA and its relationship to the λ Cro complex
por: Hall, Branwen M, et al.
Publicado: (2019)

Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA
por: Shi, Honglue, et al.
Publicado: (2021)

Crystal structure of DNA gyrase B′ domain sheds lights on the mechanism for T-segment navigation
por: Fu, Guangsen, et al.
Publicado: (2009)

Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway
por: Moure, Carmen M., et al.
Publicado: (2008)

Crystal structure of DnaT(84–153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode
por: Liu, Zheng, et al.
Publicado: (2014)

Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance
por: Chen, Xiaorong, et al.
Publicado: (2022)

TcaR–ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins
por: Chang, Yu-Ming, et al.
Publicado: (2014)

Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage ϕ29 DNA mimic protein p56
por: Baños-Sanz, José Ignacio, et al.
Publicado: (2013)

Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor
por: Noble, Christian G., et al.
Publicado: (2007)

Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation
por: Wei, Shu-Yi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_abqv1gspu4ierls3m2r97sn1om