Knockdown of Cytosolic Glutaredoxin 1 Leads to Loss of Mitochondrial Membrane Potential: Implication in Neurodegenerative Diseases

Mitochondrial dysfunction including that caused by oxidative stress has been implicated in the pathogenesis of neurodegenerative diseases. Glutaredoxin 1 (Grx1), a cytosolic thiol disulfide oxido-reductase, reduces glutathionylated proteins to protein thiols and helps maintain redox status of protei...

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Detalles Bibliográficos
Autores principales: Saeed, Uzma, Durgadoss, Lalitha, Valli, R. Khader, Joshi, Dinesh C., Joshi, Preeti G., Ravindranath, Vijayalakshmi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426930/
https://www.ncbi.nlm.nih.gov/pubmed/18560520
http://dx.doi.org/10.1371/journal.pone.0002459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426930/
https://www.ncbi.nlm.nih.gov/pubmed/18560520
http://dx.doi.org/10.1371/journal.pone.0002459

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