Capturing Pluripotency

In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We spe...

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Detalles Bibliográficos
Autores principales: Silva, Jose, Smith, Austin
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Essay
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427053/
https://www.ncbi.nlm.nih.gov/pubmed/18295569
http://dx.doi.org/10.1016/j.cell.2008.02.006
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author Silva, Jose
Smith, Austin
author_facet Silva, Jose
Smith, Austin
author_sort Silva, Jose
collection PubMed
description In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.
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spelling pubmed-24270532008-06-13 Capturing Pluripotency Silva, Jose Smith, Austin Cell Essay In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification. Cell Press 2008-02-22 /pmc/articles/PMC2427053/ /pubmed/18295569 http://dx.doi.org/10.1016/j.cell.2008.02.006 Text en © 2008 ELL & Excerpta Medica. This document may be redistributed and reused, subject to certain conditions (http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0) .
spellingShingle Essay
Silva, Jose
Smith, Austin
Capturing Pluripotency
title Capturing Pluripotency
title_full Capturing Pluripotency
title_fullStr Capturing Pluripotency
title_full_unstemmed Capturing Pluripotency
title_short Capturing Pluripotency
title_sort capturing pluripotency
topic Essay
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427053/
https://www.ncbi.nlm.nih.gov/pubmed/18295569
http://dx.doi.org/10.1016/j.cell.2008.02.006
work_keys_str_mv AT silvajose capturingpluripotency
AT smithaustin capturingpluripotency

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