Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

The Vav family of proteins are guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases, which regulate various cellular functions, including T-cell activation. They contain a catalytic Dbl homology (DH) domain that is invariably followed by a pleckstrin homology (PH) domain, which i...

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Detalles Bibliográficos
Autores principales: Rapley, Jonathan, Tybulewicz, Victor L J, Rittinger, Katrin
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Scientific Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427238/
https://www.ncbi.nlm.nih.gov/pubmed/18511940
http://dx.doi.org/10.1038/embor.2008.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427238/
https://www.ncbi.nlm.nih.gov/pubmed/18511940
http://dx.doi.org/10.1038/embor.2008.80

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