Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein

The eukaryotic La protein recognizes the 3′ poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. The 3′ ends of such RNAs are bound by the N-terminal domain of La (LaNTD). We have solved the crystal structures of four LaNTD:RNA complexes, each containing a di...

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Detalles Bibliográficos
Autores principales: Kotik-Kogan, Olga, Valentine, Elizabeth R., Sanfelice, Domenico, Conte, Maria R., Curry, Stephen
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430598/
https://www.ncbi.nlm.nih.gov/pubmed/18547518
http://dx.doi.org/10.1016/j.str.2008.02.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430598/
https://www.ncbi.nlm.nih.gov/pubmed/18547518
http://dx.doi.org/10.1016/j.str.2008.02.021

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