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Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein
The eukaryotic La protein recognizes the 3′ poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. The 3′ ends of such RNAs are bound by the N-terminal domain of La (LaNTD). We have solved the crystal structures of four LaNTD:RNA complexes, each containing a di...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430598/ https://www.ncbi.nlm.nih.gov/pubmed/18547518 http://dx.doi.org/10.1016/j.str.2008.02.021 |