Optimal Probe Length Varies for Targets with High Sequence Variation: Implications for Probe Library Design for Resequencing Highly Variable Genes

BACKGROUND: Sequencing by hybridisation is an effective method for obtaining large amounts of DNA sequence information at low cost. The efficiency of SBH depends on the design of the probe library to provide the maximum information for minimum cost. Long probes provide a higher probability of non-re...

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Detalles Bibliográficos
Autores principales: Haslam, Niall J., Whiteford, Nava E., Weber, Gerald, Prügel-Bennett, Adam, Essex, Jonathan W., Neylon, Cameron
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430613/
https://www.ncbi.nlm.nih.gov/pubmed/18563203
http://dx.doi.org/10.1371/journal.pone.0002500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430613/
https://www.ncbi.nlm.nih.gov/pubmed/18563203
http://dx.doi.org/10.1371/journal.pone.0002500

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