Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions

Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface. While most nuclear receptor LBDs form homo- or heterodimers, the human nuclear receptor pregnan...

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Detalles Bibliográficos
Autores principales: Teotico, Denise G., Frazier, Monica L., Ding, Feng, Dokholyan, Nikolay V., Temple, Brenda R. S., Redinbo, Matthew R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432469/
https://www.ncbi.nlm.nih.gov/pubmed/18617990
http://dx.doi.org/10.1371/journal.pcbi.1000111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432469/
https://www.ncbi.nlm.nih.gov/pubmed/18617990
http://dx.doi.org/10.1371/journal.pcbi.1000111

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