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Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions
Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface. While most nuclear receptor LBDs form homo- or heterodimers, the human nuclear receptor pregnan...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432469/ https://www.ncbi.nlm.nih.gov/pubmed/18617990 http://dx.doi.org/10.1371/journal.pcbi.1000111 |