Resistance of mitochondrial p53 to dominant inhibition

BACKGROUND: Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor can become contaminated with mutant p53 through hetero-tetramerization. In addition, it can be out-competed by the binding to p53 DNA recognition moti...

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Detalles Bibliográficos
Autores principales: Heyne, Kristina, Schmitt, Katrin, Mueller, Daniel, Armbruester, Vivienne, Mestres, Pedro, Roemer, Klaus
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440547/
https://www.ncbi.nlm.nih.gov/pubmed/18547443
http://dx.doi.org/10.1186/1476-4598-7-54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440547/
https://www.ncbi.nlm.nih.gov/pubmed/18547443
http://dx.doi.org/10.1186/1476-4598-7-54

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