Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment

BACKGROUND: Friedreich ataxia is a neurological disease originating from an iron-sulfur cluster enzyme deficiency due to impaired iron handling in the mitochondrion, aconitase being particularly affected. As a mean to counteract disease progression, it has been suggested to chelate free mitochondria...

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Detalles Bibliográficos
Autores principales: Goncalves, Sergio, Paupe, Vincent, Dassa, Emmanuel P, Rustin, Pierre
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440763/
https://www.ncbi.nlm.nih.gov/pubmed/18558000
http://dx.doi.org/10.1186/1471-2377-8-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440763/
https://www.ncbi.nlm.nih.gov/pubmed/18558000
http://dx.doi.org/10.1186/1471-2377-8-20

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